Mvptm1Wie
Targeted Allele Detail
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| Symbol: |
Mvptm1Wie |
| Name: |
major vault protein; targeted mutation 1, Erik A C Wiemer |
| MGI ID: |
MGI:2447742 |
| Synonyms: |
MVP- |
| Gene: |
Mvp Location: Chr7:126586036-126613729 bp, - strand Genetic Position: Chr7, 69.26 cM, cytoband F4
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| Alliance: |
Mvptm1Wie page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:80831
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| Parent Cell Line: |
E14 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The gene was disrupted by replacement of exons 5-7 with a neomycin resistance cassette via homologous recombination. Absence of gene expression was confirmed by Northern and Western blot analysis. Gene transcript was not detectable in liver RNA from homozygous mutant animals, and protein product was not observed in several tissues tested.
(J:80831)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Mvp Mutation: |
60 strains or lines available
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| Original: |
J:80831 Mossink MH, et al., Disruption of the murine major vault protein (MVP/LRP) gene does not induce hypersensitivity to cytostatics. Cancer Res. 2002 Dec 15;62(24):7298-304 |
| All: |
5 reference(s) |
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Analysis Tools
