Mnx1^tm1Jhk
Targeted Allele Detail

Summary

• Symbol: Mnx1^tm1Jhk
• Name: motor neuron and pancreas homeobox 1; targeted mutation 1, John H Kehrl
• MGI ID: MGI:2447781
• Synonyms: Hlxb9^-
• Gene: Mnx1 Location: Chr5:29678821-29683468 bp, - strand Genetic Position: Chr5, 15.04 cM
• Alliance: Mnx1^tm1Jhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57314
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 3 was flanked with a neo cassette and loxP sites via homologous recombination. Transient expression of cre recombinase in correctly targeted ES cells facilitated removal of the neo cassette and exon 3 leaving behind a single loxP site in its place. Exon 3 encodes the C-terminal portion of the homeodomain and the remainder of the protein. (J:57314)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mnx1 Mutation: 29 strains or lines available

References

• Original: J:57314 Harrison KA, et al., Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nat Genet. 1999 Sep;23(1):71-5
• All: 11 reference(s)