Ikzf1tm1(Pax5)Mbu
Targeted Allele Detail
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Symbol: |
Ikzf1tm1(Pax5)Mbu |
Name: |
IKAROS family zinc finger 1; targeted mutation 1, Meinrad Busslinger |
MGI ID: |
MGI:2447783 |
Synonyms: |
Ikneo |
Gene: |
Ikzf1 Location: Chr11:11634980-11722926 bp, + strand Genetic Position: Chr11, 7.02 cM
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Alliance: |
Ikzf1tm1(Pax5)Mbu page
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Germline Transmission: |
Earliest citation of germline transmission:
J:80815
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Parent Cell Line: |
HM-1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd-Hprt1b-m3
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Allele Type: |
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Targeted (Conditional ready, Inserted expressed sequence, Null/knockout) |
Mutation: |
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Insertion
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Mutation details: A construct containing a floxed neo cassette, Pax5 gene, and GFP gene was inserted into the Znfn1a1 locus upstream of the translation initiation codon in exon 2. Western blot analysis using antibodies against C-terminal Znfn1a1 sequences did not detect protein product in thymocytes from homozygous mutant animals. Trace amounts of Pax5 protein was detected in thymocytes.
(J:80815)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ikzf1 Mutation: |
30 strains or lines available
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Original: |
J:80815 Souabni A, et al., Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1. Immunity. 2002 Dec;17(6):781-93 |
All: |
6 reference(s) |
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