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Ikzf1tm1.1(Pax5)Mbu
Targeted Allele Detail
Summary
Symbol: Ikzf1tm1.1(Pax5)Mbu
Name: IKAROS family zinc finger 1; targeted mutation 1.1, Meinrad Busslinger
MGI ID: MGI:2447787
Synonyms: IkPax5
Gene: Ikzf1  Location: Chr11:11634980-11722926 bp, + strand  Genetic Position: Chr11, 7.02 cM
Alliance: Ikzf1tm1.1(Pax5)Mbu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80815
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe floxed neo cassette in exon 2 was removed by mating Znfn1a1tm1(Pax)Mbu animals to cre expressing line TgN(Sycp1-cre)4Min, thus allowing expression from the Pax5-GFP cassette inserted at Znfn1a1. Western blot analysis detected Pax5 protein expression in thymocytes and myeloid cells at levels similar to wild-type. GFP expression in B cells was detected by flow cytometric analysis. (J:80815)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikzf1 Mutation:  30 strains or lines available
References
Original:  J:80815 Souabni A, et al., Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1. Immunity. 2002 Dec;17(6):781-93
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory