Tg(APOC1)1Bres
Transgene Detail

Summary

• Symbol: Tg(APOC1)1Bres
• Name: transgene insertion 1, Jan L Breslow
• MGI ID: MGI:2447788
• Transgene: Tg(APOC1)1Bres Location: unknown
• Alliance: Tg(APOC1)1Bres page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOC1)1Bres expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOC1 (341)

  Apoc1

  (MGI:88053)

• Mutation details: The transgene consists of a liver specific enhancer element and a genomic DNA fragment containing human APOC1 with 3 kb of 5' flanking sequences and 2.5 kb of 3' flanking sequences. RNase protection assay confirmed transgene expression exclusively in the liver. (J:80950)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:80950 Shachter NS, et al., Combined hyperlipidemia in transgenic mice overexpressing human apolipoprotein Cl. J Clin Invest. 1996 Aug 1;98(3):846-55
• All: 2 reference(s)