Tns1^tm1Efu
Targeted Allele Detail

Summary

• Symbol: Tns1^tm1Efu
• Name: tensin 1; targeted mutation 1, Elaine Fuchs
• MGI ID: MGI:2447792
• Synonyms: Tensn -/-
• Gene: Tns1 Location: Chr1:73949390-74163608 bp, - strand Genetic Position: Chr1, 38.17 cM
• Alliance: Tns1^tm1Efu page

Kidney abnormalities in Tns1^tm1Efu/Tns1^tm1Efu mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39202
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A region encoding amino acids 110-180 was replaced with a neomycin cassette. This replacement disrupts both of the transcripts encoded by this gene. Immunoblot analysis on extracts of skin fibroblasts derived from homozygous mice confirmed that no detectable protein is made from this allele. (J:39202)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tns1 Mutation: 85 strains or lines available

References

• Original: J:39202 Lo SH, et al., Progressive kidney degeneration in mice lacking tensin. J Cell Biol. 1997 Mar 24;136(6):1349-61
• All: 5 reference(s)