Lin7a^tm1Dsb
Targeted Allele Detail

Summary

• Symbol: Lin7a^tm1Dsb
• Name: lin-7 homolog A, crumbs cell polarity complex component; targeted mutation 1, David S Bredt
• MGI ID: MGI:2447803
• Synonyms: MALS-1 KO
• Gene: Lin7a Location: Chr10:107107547-107257335 bp, + strand Genetic Position: Chr10, 55.83 cM
• Alliance: Lin7a^tm1Dsb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68187
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded 39 amino acids. Western blot analysis of brain homogenates indicated an absence of protein in homozygous mutant mice. (J:68187)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lin7a Mutation: 23 strains or lines available

References

• Original: J:68187 Misawa H, et al., Contrasting localizations of mals/lin-7 pdz proteins in brain and molecular compensation in knockout mice. J Biol Chem. 2001 Mar 23;276(12):9264-72
• All: 4 reference(s)