Tg(Gfap-Ifna1)12Ilc
Transgene Detail

Summary

• Symbol: Tg(Gfap-Ifna1)12Ilc
• Name: transgene insertion 12, Iain L Campbell
• MGI ID: MGI:2447805
• Synonyms: GIFN12
• Transgene: Tg(Gfap-Ifna1)12Ilc Location: unknown
• Alliance: Tg(Gfap-Ifna1)12Ilc page

Transgene origin

• Strain of Origin: (C57BL/6J x BALB/c)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Gfap-Ifna1)12Ilc expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ifna1 (MGI:107668)

• Mutation details: A Gfap promoter and mouse Ifna1 cDNA sequence cloned between an upstream SV40 intron and downstream SV40 polyadenylation signal was used for the transgene. The GFAP promoter directs transgene expression in the astrocytes. Transgene expression in the brain was confirmed by RNase protection assay. (J:68811)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Gfap-Ifna1)12Ilc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:68811 Akwa Y, et al., Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration. J Immunol. 1998 Nov 1;161(9):5016-26
• All: 13 reference(s)