Stat2^tm1Shnd
Targeted Allele Detail

Summary

• Symbol: Stat2^tm1Shnd
• Name: signal transducer and activator of transcription 2; targeted mutation 1, Christian Schindler
• MGI ID: MGI:2447829
• Synonyms: Stat2^-/-
• Gene: Stat2 Location: Chr10:128106428-128128718 bp, + strand Genetic Position: Chr10, 76.5 cM
• Alliance: Stat2^tm1Shnd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66564
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 1-4 with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by Western blot analysis of primary mouse embryonic fibroblast (PMEF) extracts prepared from homozygous mutant embryos. Stat1 expression was reduced by 50% in Stat2-deficient cells. (J:66564)

Tumor Data

List all tumor models in MMHCdb carrying Stat2^tm1Shnd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Stat2 Mutation: 39 strains or lines available

References

• Original: J:66564 Park C, et al., Immune response in Stat2 knockout mice. Immunity. 2000 Dec;13(6):795-804
• All: 47 reference(s)