Tg(RHO-SCA7)R7NJman
Transgene Detail

Summary

• Symbol: Tg(RHO-SCA7)R7NJman
• Name: transgene insertion R7N, Jean-Louis Mandel
• MGI ID: MGI:2447847
• Synonyms: R7N
• Transgene: Tg(RHO-SCA7)R7NJman Location: unknown
• Alliance: Tg(RHO-SCA7)R7NJman page

Aberrant retinal rod chromatin remodeling and segment loss in Tg(RHO-SCA7)R7EJman/0 mice compared to normal retinas in Tg(RHO-SCA7)R7NJman/0 mice

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(RHO-SCA7)R7NJman expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATXN7 (6314)

  Atxn7

  (MGI:2179277)

• Mutation details: The transgene consists of a human rhodopsin promoter (containing the RER enhancer element), the full-length wild-type human Sca7 gene carrying 10 glutamine repeat units, and an SV40 intron and polyadenylation sequence. Transgene expression was observed in rod cells by immunofluorescence, and in retinal extracts by Western blot. (J:65411)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Transgenic lines A, B, and C were constructed. Line C carries 50-100 copies of the integrated transgene and expresses the highest amount of transgene product.

References

• Original: J:65411 Yvert G, et al., Expanded polyglutamines induce neurodegeneration and trans-neuronal alterations in cerebellum and retina of SCA7 transgenic mice. Hum Mol Genet. 2000 Oct 12;9(17):2491-506
• All: 2 reference(s)