Clcn3^tm1Lamb
Targeted Allele Detail

Summary

• Symbol: Clcn3^tm1Lamb
• Name: chloride channel, voltage-sensitive 3; targeted mutation 1, Fred S Lamb
• MGI ID: MGI:2447864
• Synonyms: Clcn3^-
• Gene: Clcn3 Location: Chr8:61363423-61436334 bp, - strand Genetic Position: Chr8, 30.9 cM
• Alliance: Clcn3^tm1Lamb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80901
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing a portion of exon 6 and all of exon 7 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded a portion of transmembrane domain 2 and all of transmembrane domains 3 and 4. Protein was undetected by Western blot analysis of brain tissue obtained from homozygous mutant mice. (J:80901)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clcn3 Mutation: 120 strains or lines available

References

• Original: J:80901 Dickerson LW, et al., Altered GABAergic function accompanies hippocampal degeneration in mice lacking ClC-3 voltage-gated chloride channels. Brain Res. 2002 Dec 27;958(2):227-50
• All: 15 reference(s)