Ccr8^tm1Lira
Targeted Allele Detail

Summary

• Symbol: Ccr8^tm1Lira
• Name: C-C motif chemokine receptor 8; targeted mutation 1, Sergio A Lira
• MGI ID: MGI:2447888
• Synonyms: CCR8^-
• Gene: Ccr8 Location: Chr9:119921199-119923972 bp, + strand Genetic Position: Chr9, 71.39 cM, cytoband F4
• Alliance: Ccr8^tm1Lira page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67918
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of the entire Ccr8 coding sequence with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of lung mRNA. (J:67918)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccr8 Mutation: 41 strains or lines available

References

• Original: J:67918 Chensue SW, et al., Aberrant in vivo t helper type 2 cell response and impaired eosinophil recruitment in cc chemokine receptor 8 knockout mice. J Exp Med. 2001 Mar 5;193(5):573-84
• All: 20 reference(s)