Ods^{Tg(Dct-Tyr)1220Ove}
Transgenic Allele Detail

Summary

• Symbol: Ods^{Tg(Dct-Tyr)1220Ove}
• Name: ocular degeneration with sex reversal; transgene insertion 1220, Paul Overbeek
• MGI ID: MGI:2447988
• Synonyms: Ods, Ods^{Tg(Tyr)1220Ove}, OVE1220
• Gene: Ods Location: unknown Genetic Position: Chr11, Syntenic
• Alliance: Ods^{Tg(Dct-Tyr)1220Ove} page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutations: Deletion, Insertion
• Ods^{Tg(Dct-Tyr)1220Ove} involves 1 genes/genome features (Ods) View all
• Mutation details: Two copies of a transgene inserted randomly 1 Mb upstream of the Sox9 gene, and also caused a deletion of 150 kb at the insertion site. The transgene consisted of Dct promoter sequence driving expression of a tyrosinase minigene. (J:66268)

Tumor Data

List all tumor models in MMHCdb carrying Ods^{Tg(Dct-Tyr)1220Ove}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ods Mutation: 0 strains or lines available

Notes

This mutation is proposed to delete a long-range regulatory element that mediates expression of Sox9 in a gender specific manner.

References

• Original: J:66268 Bishop CE, et al., A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse. Nat Genet. 2000 Dec;26(4):490-4
• All: 8 reference(s)