hb
Transgenic Allele Detail

Summary

• Symbol: hb
• Name: head bobber
• MGI ID: MGI:2447989
• Synonyms: OVE7
• Gene: hb Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: hb page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic
• Mutation: Insertion
• Mutation details: This mutation was isolated during the production of an unrelated transgenic line. Both the hb mutation and the transgene insertion site map to a similar chromosomal location, suggesting that the transgene insertion disrupts the normal function of a gene resulting in the phenotype. The transgene contains the human ACTB promoter, exon 1 and intron 1 and a neomycin resistance cassette. A 648 kb deletion on chromosome 7 results in the loss of Gpr26, Cpxm2 and Chst15) and an indirect long range effect on the expression of neighboring genes including Hmx3, Hmx2 and Nkx1.2. (J:197180, J:199713)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any hb Mutation: 2 strains or lines available

References

• Original: J:48656 Hughes D, et al., Characterisation of the mouse mutant headbobber (hb). Hered Deaf News. 1998;15:35
• All: 4 reference(s)