Dync1h1^Loa
Chemically induced Allele Detail

Summary

• Symbol: Dync1h1^Loa
• Name: dynein cytoplasmic 1 heavy chain 1; legs at odd angles
• MGI ID: MGI:2447991
• Synonyms: Loa
• Gene: Dync1h1 Location: Chr12:110567886-110633379 bp, + strand Genetic Position: Chr12, 60.7 cM
• Alliance: Dync1h1^Loa page

Mutation origin

• Strain of Origin: C3H/HeH

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A phenotypic mutant that arose in a mutagenesis experiment at Harwell. Loa was found to be allelic to Cra1 through complementation testing. The mutation in the Loa mouse was identified as T to A transversion that results in the amino acid change of a phenylalanine to a tyrosine at position 580. (J:83128)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dync1h1 Mutation: 195 strains or lines available

References

• Original: J:76724 Rogers DC, et al., SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice. Neurosci Lett. 2001 Jun 22;306(1-2):89-92
• All: 17 reference(s)