Sox2^lcc
Radiation induced Allele Detail

Summary

• Symbol: Sox2^lcc
• Name: SRY (sex determining region Y)-box 2; light coat and circling
• MGI ID: MGI:2447995
• Synonyms: In(3)9H
• Gene: Sox2 Location: Chr3:34704554-34706610 bp, + strand Genetic Position: Chr3, 16.93 cM, cytoband A2-B
• Alliance: Sox2^lcc page

Mutation origin

• Strain of Origin: C3H/HeH x 101/H

Mutation description

• Allele Type: Radiation induced
• Mutation: Inversion
• Sox2^lcc involves 205 genes/genome features (Gm26678, Exosc9, Ccna2 ...) View all
• Mutation details: A mutation recovered in a radiation mutagenesis experiment. Molecular analysis revealed an inversion with breakpoints at B and E1. Genetic noncomplementation tests with a targeted mutation indicated that this mutation is an allele of Sox2. Genomic PCR analysis showed that the coding region and nearby flanking DNA was intact in the mutants. Expression of the gene was intact in most of the developing neural tube but was not detected in the otocyst or adjacent region of the hindbrain, in contrast to controls. This tissue specific loss is thought to be due to loss or translocation of tissue-specific regulatory elements. (J:98458)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sox2 Mutation: 56 strains or lines available

References

• Original: J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
• All: 5 reference(s)