Sox2^ysb
Transgenic Allele Detail

Summary

• Symbol: Sox2^ysb
• Name: SRY (sex determining region Y)-box 2; yellow submarine
• MGI ID: MGI:2447996
• Synonyms: KM12
• Gene: Sox2 Location: Chr3:34704554-34706610 bp, + strand Genetic Position: Chr3, 16.93 cM, cytoband A2-B
• Alliance: Sox2^ysb page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic
• Mutation: Intragenic deletion
• Mutation details: This mutation arose as the result of the random insertion of an unrelated transgene. Molecular analysis indicated that two integration sites had occurred on chromosome 3 and a 20 kb deletion was also associated with one of these integration sites. Genetic noncomplementation tests with a targeted mutation indicated that this mutation is an allele of Sox2. Genomic PCR analysis showed that the coding region and nearby flanking DNA was intact in the mutants. Expression of the gene was severely reduced in the otocyst, in contrast to controls. This tissue specific loss is thought to be due to juxtaposition of the inserted transgenic reporter construct that interferes with the function of tissue-specific regulatory elements. (J:98458)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox2 Mutation: 56 strains or lines available

References

• Original: J:77358 Dong S, et al., Circling, deafness, and yellow coat displayed by yellow submarine (ysb) and light coat and circling (lcc) mice with mutations on chromosome 3. Genomics. 2002 Jun;79(6):777-84
• All: 4 reference(s)