Disp1^icb
Chemically induced Allele Detail

Summary

• Symbol: Disp1^icb
• Name: dispatched RND transporter family member 1; icbins
• MGI ID: MGI:2448055
• Synonyms: Disp1^C829F
• Gene: Disp1 Location: Chr1:182867830-183003086 bp, - strand Genetic Position: Chr1, Syntenic
• Alliance: Disp1^icb page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation in the icbins mouse was identified as a G-to-T mutation that changed a cysteine to a phenylalanine at amino acid position 829 (p.C829F). This mutation affects a predicted extracellular loop containing 6 highly conserved cysteine residues. (J:79027)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	24 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Disp1 Mutation: 61 strains or lines available

References

• Original: J:79027 Caspary T, et al., Mouse dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling. Curr Biol. 2002 Sep 17;12(18):1628-32
• All: 7 reference(s)