Bmp3^tm1Kml
Targeted Allele Detail

Summary

• Symbol: Bmp3^tm1Kml
• Name: bone morphogenetic protein 3; targeted mutation 1, Karen M Lyons
• MGI ID: MGI:2448071
• Synonyms: Bmp3^-
• Gene: Bmp3 Location: Chr5:99002274-99031912 bp, + strand Genetic Position: Chr5, 48.24 cM
• Alliance: Bmp3^tm1Kml page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75187
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.8 kb fragment containing exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded most of the precursor region, the proteolytic processing site, and two thrids of the mature region. RT-PCR analysis indicated an absence of normal transcript in homozygous mutant mice. (J:75187)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmp3 Mutation: 26 strains or lines available

References

• Original: J:75187 Daluiski A, et al., Bone morphogenetic protein-3 is a negative regulator of bone density. Nat Genet. 2001 Jan;27(1):84-8
• All: 3 reference(s)