Ccr3^tm1Cge
Targeted Allele Detail

Summary

• Symbol: Ccr3^tm1Cge
• Name: C-C motif chemokine receptor 3; targeted mutation 1, Craig Gerard
• MGI ID: MGI:2448180
• Synonyms: CCR3-, CCR3 KO
• Gene: Ccr3 Location: Chr9:123822009-123831726 bp, + strand Genetic Position: Chr9, 75.05 cM, cytoband F
• Alliance: Ccr3^tm1Cge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74509
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of a 3 kb region containing the start codon, 39 bp of the N-terminal coding region, and the 5' untranslated region with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by RT-PCR analysis of bone marrow mRNA from homozygous mutant animals. (J:74509)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccr3 Mutation: 30 strains or lines available

References

• Original: J:74509 Humbles AA, et al., The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1479-84
• All: 31 reference(s)