Ltf^tm1Omc
Targeted Allele Detail

Summary

• Symbol: Ltf^tm1Omc
• Name: lactotransferrin; targeted mutation 1, Orla M Conneely
• MGI ID: MGI:2448243
• Synonyms: LFKO^-
• Gene: Ltf Location: Chr9:110848360-110871834 bp, + strand Genetic Position: Chr9, 60.79 cM, cytoband F
• Alliance: Ltf^tm1Omc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81005
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The iron binding domain was disrupted with a neomcycin selection cassette that replaced a portion of exon 5 through exon 9. Protein was undetected by Western blot analysis of milk obtained from homozygous mutant mice. (J:81005)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ltf Mutation: 41 strains or lines available

References

• Original: J:81005 Ward PP, et al., Iron status in mice carrying a targeted disruption of lactoferrin. Mol Cell Biol. 2003 Jan;23(1):178-85
• All: 2 reference(s)