Ebi3^tm1Rsb
Targeted Allele Detail

Summary

• Symbol: Ebi3^tm1Rsb
• Name: Epstein-Barr virus induced gene 3; targeted mutation 1, Richard Blumberg
• MGI ID: MGI:2448308
• Synonyms: EBI-3, EBI3^-, Ebi3^tm1Birk, EBI3^{tm Birk}
• Gene: Ebi3 Location: Chr17:56259640-56264022 bp, + strand Genetic Position: Chr17, 29.08 cM
• Alliance: Ebi3^tm1Rsb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81014
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing exons 2 through 5 was replaced by a neomycin selection cassette inserted by homologous recombination. Northern blot analysis of splenic RNA indicated an absence of normal transcript in homozygous mutant mice. (J:81014)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ebi3 Mutation: 12 strains or lines available

References

• Original: J:81014 Nieuwenhuis EE, et al., Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16951-6
• All: 40 reference(s)