Gap43^tm1Mcf
Targeted Allele Detail

Summary

• Symbol: Gap43^tm1Mcf
• Name: growth associated protein 43; targeted mutation 1, Mark C Fishman
• MGI ID: MGI:2448337
• Gene: Gap43 Location: Chr16:42068915-42161014 bp, - strand Genetic Position: Chr16, 28.37 cM
• Alliance: Gap43^tm1Mcf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22966
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which contains approximately 85% of the coding sequence, was replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of brain tissue obtained from homozygous mutant mice. The absenceof protein was also indicated by immunohistochemical analysis of neurons. (J:22966)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gap43 Mutation: 27 strains or lines available

References

• Original: J:22966 Strittmatter SM, et al., Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43. Cell. 1995 Feb 10;80(3):445-52
• All: 7 reference(s)