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Gap43tm1Mcf
Targeted Allele Detail
Summary
Symbol: Gap43tm1Mcf
Name: growth associated protein 43; targeted mutation 1, Mark C Fishman
MGI ID: MGI:2448337
Gene: Gap43  Location: Chr16:42068915-42161014 bp, - strand  Genetic Position: Chr16, 28.37 cM
Alliance: Gap43tm1Mcf page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:22966
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2, which contains approximately 85% of the coding sequence, was replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of brain tissue obtained from homozygous mutant mice. The absenceof protein was also indicated by immunohistochemical analysis of neurons. (J:22966)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gap43 Mutation:  27 strains or lines available
References
Original:  J:22966 Strittmatter SM, et al., Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43. Cell. 1995 Feb 10;80(3):445-52
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory