Syn1^tm1Pggd
Targeted Allele Detail

Summary

• Symbol: Syn1^tm1Pggd
• Name: synapsin I; targeted mutation 1, Paul Greengard
• MGI ID: MGI:2448356
• Synonyms: Syn1^tm1Lli, SynI^-
• Gene: Syn1 Location: ChrX:20726750-20787157 bp, - strand Genetic Position: ChrX, 16.37 cM, cytoband A1-A4
• Alliance: Syn1^tm1Pggd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29085
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced by a neomycin selection cassette inserted by homologous recombination. Western blot analysis of homozygous mutant brain tissues indicated an absence of both protein isoforms, Synapsin Ia and Synapsin Ib, produced by the endogenous locus. (J:29085)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Syn1 Mutation: 22 strains or lines available

References

• Original: J:29085 Chin LS, et al., Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice. Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9230-4
• All: 48 reference(s)