Tg(MMTV-ERBB3)1Slg
Transgene Detail

Summary

• Symbol: Tg(MMTV-ERBB3)1Slg
• Name: transgene insertion 1, Stanton L Gerson
• MGI ID: MGI:2448360
• Synonyms: MMTVhuman-erb-B-3
• Transgene: Tg(MMTV-ERBB3)1Slg Location: unknown
• Alliance: Tg(MMTV-ERBB3)1Slg page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-ERBB3)1Slg expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ERBB3 (2065)

  Erbb3

  (MGI:95411)

• Mutation details: The transgene consists of an MMTV promoter, a human ERBB3 cDNA, and the bovine growth hormone exon 5 and polyadenylation sequence. The MMTV promoter was used to overexpress the human transgene in lung and mammary glands of transgenic mice. Transgenic animals express human ERBB3 mRNA in lung, mammary gland, brain, intestine, thymus, liver, and spleen as determined by RT-PCR analyisis. (J:80974)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:80974 Zhou H, et al., Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea. Oncogene. 2002 Dec 12;21(57):8732-40
• All: 1 reference(s)