Ptprcap^tm1Tkda
Targeted Allele Detail

Summary

• Symbol: Ptprcap^tm1Tkda
• Name: protein tyrosine phosphatase receptor type C polypeptide-associated protein; targeted mutation 1, Akiko Takeda
• MGI ID: MGI:2448362
• Gene: Ptprcap Location: Chr19:4204645-4206709 bp, + strand Genetic Position: Chr19, 3.86 cM, cytoband B
• Alliance: Ptprcap^tm1Tkda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48387
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding the first isoform and all but 5 amino terminal residues of the second isoform was replaced with a neomycin selection cassette. Protein was undetected by Western blot analysis of spleen cells and thymocytes obtained from homozygous mutant mice. (J:48387)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptprcap Mutation: 20 strains or lines available

References

• Original: J:48387 Matsuda A, et al., Disruption of lymphocyte function and signaling in CD45-associated protein-null mice. J Exp Med. 1998 Jun 1;187(11):1863-70
• All: 1 reference(s)