Epha2^{Gt(ROSABetageo)CN3Yiw}
Gene trapped Allele Detail

Summary

• Symbol: Epha2^{Gt(ROSABetageo)CN3Yiw}
• Name: Eph receptor A2; gene trap CN3, Yoichiro Iwakura
• MGI ID: MGI:2448472
• Synonyms: EphA2^LacZ
• Gene: Epha2 Location: Chr4:141028551-141056695 bp, + strand Genetic Position: Chr4, 73.67 cM, cytoband D-E
• Alliance: Epha2^{Gt(ROSABetageo)CN3Yiw} page

Mutation origin

• Mutant Cell Line: CN3
• Germline Transmission: Earliest citation of germline transmission: J:69393
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: ROSANBeta-geo Vector Type: gene trap
• Mutation details: A gene trap vector inserted into intron 1. Southern blot analysis indicated that the insertion occurred at a single site in the genome. Normal transcript was undetected by Northern blot analysis. An absence of full length protein was indicated by Western blot analysis. (J:69393)

Expression

In Mice Carrying this Mutation:	52 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Epha2 Mutation: 96 strains or lines available

References

• Original: J:69393 Naruse-Nakajima C, et al., Involvement of EphA2 in the formation of the tail notochord via interaction with ephrinA1. Mech Dev. 2001 Apr;102(1-2):95-105
• All: 8 reference(s)