F2rl1^tm1Wrf
Targeted Allele Detail

Summary

• Symbol: F2rl1^tm1Wrf
• Name: F2R like trypsin receptor 1; targeted mutation 1, William R Ferrell
• MGI ID: MGI:2448473
• Synonyms: PAR-2^-
• Gene: F2rl1 Location: Chr13:95648240-95661735 bp, - strand Genetic Position: Chr13, 49.53 cM
• Alliance: F2rl1^tm1Wrf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81119
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 813 nt were replaced with an IRES-lacZ and neo cassette inserted into exon 2 by homologous recombination. LacZ expression was identified by x-gal staining. (J:81119)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F2rl1 Mutation: 60 strains or lines available

References

• Original: J:81119 Ferrell WR, et al., Essential role for proteinase-activated receptor-2 in arthritis. J Clin Invest. 2003 Jan;111(1):35-41
• All: 12 reference(s)