Tg(Pbsn-FGFR2_iiib*)#Ng
Transgene Detail

Summary

• Symbol: Tg(Pbsn-FGFR2_iiib*)#Ng
• Name: transgene insertion, Norman M Greenberg
• MGI ID: MGI:2448655
• Synonyms: KDNR
• Transgene: Tg(Pbsn-FGFR2_iiib*)#Ng Location: unknown
• Alliance: Tg(Pbsn-FGFR2_iiib*)#Ng page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence, Modified isoform(s))
• Mutation: Insertion
• Mutation details: The transgene consists of a rat Pbsn minimal promoter and a dominant negative human FGFR2 (isoform iiib) cDNA. The rat probasin minimal promoter (-426 to +28) was used to drive transgene expression in prostate epithelium. Three lines were established: 3260, 3425, 5806, however, the pound symbol (#) is used when lines are pooled. (J:80821)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Pbsn-FGFR2_iiib*)#Ng

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Three transgenic lines (3260, 3425, and 5806) were created. The prostates of transgenic animals are visibly smaller compared to wild-type.

References

• Original: J:80821 Foster BA, et al., Enforced expression of FGF-7 promotes epithelial hyperplasia whereas a dominant negative FGFR2iiib promotes the emergence of neuroendocrine phenotype in prostate glands of transgenic mice. Differentiation. 2002 Dec;70(9-10):624-32
• All: 2 reference(s)