Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Expression |
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Notes |
Dbsty3 shows evidence of complex interactions with other diabesity loci.
Candidate Genes
The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/Avy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/Avy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. Mapping and Phenotype information for this QTL, its variants and associated markersJ:65256Genome scan at an average density of 20 cM was performed on a population of 203 NON/Lt x (NZO/HlLt x NON/Lt)F1 backcross male animals to identify loci associated with diabesity. The New Zealand Obese (NZO) strain develops early onset diabetes, and exhibits impaired glucose tolerance (IGT), insulin resistance and leptin resistance. The Nonobese Nondiabetic (NON) strain does not develop diabetes or obesity, exhibits normal leptin levels, but shows IGT and low insulin responses. A broad QTL was detected on mouse Chromosome 1 from 8.3 cM - 43.1 cM and encompasses a variety of diabesity traits such as increased body weight, elevated plasma glucose levels, and early hyperinsulinemia. This locus, Dbsty1 (diabesity), appears to peak at approximately 21 cM near D1Mit123 with a LOD = 9.36 for body weight at 8 weeks of age. Dbsty2 is associated with adiposity index and maps to mouse Chromosome 5 at 45 cM with a LOD = 3.86 at D5Mit7. Dbsty3 maps to mouse Chromosome 12 from 45 cM - 53 cM with a peak LOD = 4.88 at D12Mit231 and is associated with body mass index, adiposity index, and leptin levels. Dbsty4 maps to mouse Chromosome 15 at approximately 49.6 cM with a peak LOD = 3.55 at D15Mit159 and is associated with plasma glucose. Inheritance of NZO-derived alleles atdiabesity QTLs act to increase diabesity traits. Suggestive QTLs mapped to mouse Chromosome 3 for plasma insulin levels (LOD = 2.53 at D3Mit22), mouse Chromosome 6 for body weight, body mass index, plasma insulin, adiposity index, and leptin levels (peakLOD = 3.42 at D6Mit123), mouse Chromosome 13 for body mass index (LOD = 2.03 at D13Mit53), and mouse Chromosome 18 for body mass index and adiposity index (LOD = 2.47 at D18Mit60). Complex interactions were detected among the diabesity QTLs as well as other loci. See article for details. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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