Tg(APOB)1102Sgy
Transgene Detail

Summary

• Symbol: Tg(APOB)1102Sgy
• Name: transgene insertion 1102, Stephen G Young
• MGI ID: MGI:2448678
• Synonyms: 1102, hApoB, TgN(hApoB)1102SY
• Transgene: Tg(APOB)1102Sgy Location: unknown
• Alliance: Tg(APOB)1102Sgy page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOB)1102Sgy expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOB (338)

  Apob	(MGI:88052)

• Mutation details: The transgene contains a 79.5 kb P1 insert with the entire human APOB gene. RNA slot blot analysis detected transgene expression in the liver, with very small amounts expressed in the small intestine and heart. Western blot analysis of plasma from transgenic animals showed human apo-B100 as the predominant species of transgene product. (J:81265)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

Founder 1102 carries 10 copies of the human APOB transgene and expresses the highest amount of transgene product. Nine other founder lines (4-42 copies of the transgene) were also established.

References

• Original: J:81265 Linton MF, et al., Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a). J Clin Invest. 1993 Dec;92(6):3029-37
• All: 33 reference(s)