Tg(Edn1-NOS3)22Yky
Transgene Detail

Summary

• Symbol: Tg(Edn1-NOS3)22Yky
• Name: transgene insertion 22, Mitsuhiro Yokoyama
• MGI ID: MGI:2448699
• Synonyms: eNOS-Tg, Tg(Edn1-NOS3)1Yky
• Transgene: Tg(Edn1-NOS3)22Yky Location: unknown
• Alliance: Tg(Edn1-NOS3)22Yky page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Edn1-NOS3)22Yky expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  cattle	NOS3 (287024)

• Mutation details: The transgene consists of a mouse Edn1 promoter, active in the vascular wall, and a bovine NOS3 cDNA. RNase protection assay detected transgene expression in heart, lung, aorta, and uterus. Low levels of transgene expression was also observed in brain, liver, kidney, and intestine. (J:81132)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Four transgenic lines (22, 65, 88, and 105) were established.

References

• Original: J:81132 Ohashi Y, et al., Hypotension and reduced nitric oxide-elicited vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase. J Clin Invest. 1998 Dec 15;102(12):2061-71
• All: 23 reference(s)