Tg(BCL2/IGH)1Tjd
Transgene Detail

Summary

• Symbol: Tg(BCL2/IGH)1Tjd
• Name: transgene insertion 1, Timothy J McDonnell
• MGI ID: MGI:2448738
• Synonyms: bcl-1-Ig NL, hbcl-2-Ig
• Transgene: Tg(BCL2/IGH)1Tjd Location: unknown
• Alliance: Tg(BCL2/IGH)1Tjd page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H/He)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(BCL2/IGH)1Tjd expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BCL2 (596)

  Bcl2	(MGI:88138)

  Transgene codes for a fusion protein of human BCL2 and IGH.

  human

  IGH (3492)

  Transgene codes for a fusion protein of human BCL2 and IGH.

• Mutation details: A human genomic BCL2/IGH fusion minigene was used for the transgene. This construct represents a translocation mutation, t(14:18), found in human follicular B cell lymphomas. The entire wild-type sequence of BCL2 was used. Because of the large size of BCL2 intron 2 (350 kb), a cDNA segment of the exon II/exon III junction was substituted. Transgene expression in the spleen and thymus was confirmed by S1 nuclease protection assay. (J:81147)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Five transgenic lines (M-14, M-30, M-43, M-59, and M-62) were established.

References

• Original: J:81147 McDonnell TJ, et al., bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell. 1989 Apr 7;57(1):79-88
• All: 11 reference(s)