Jak1^tm1Rds
Targeted Allele Detail

Summary

• Symbol: Jak1^tm1Rds
• Name: Janus kinase 1; targeted mutation 1, Robert D Schreiber
• MGI ID: MGI:2448928
• Synonyms: Jak1^-
• Gene: Jak1 Location: Chr4:101009564-101122479 bp, - strand Genetic Position: Chr4, 46.19 cM
• Alliance: Jak1^tm1Rds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47300
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 1 and 2 and 1.6 kb of 5' upstream sequence with a neomycin resistance cassette via homologous recombination. Absence of gene expression was confirmed by Western blot analysis of embryonic fibroblasts derived from homozygous mutant embryos. (J:47300)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jak1 Mutation: 50 strains or lines available

References

• Original: J:47300 Rodig SJ, et al., Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell. 1998 May 1;93(3):373-83
• All: 3 reference(s)