Nrtn^tm1Jmi
Targeted Allele Detail

Summary

• Symbol: Nrtn^tm1Jmi
• Name: neurturin; targeted mutation 1, Jeffrey Milbrandt
• MGI ID: MGI:2448936
• Synonyms: Nrtn-, NTN-
• Gene: Nrtn Location: Chr17:57058325-57064530 bp, - strand Genetic Position: Chr17, 29.49 cM
• Alliance: Nrtn^tm1Jmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53261
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of the entire coding region with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of heart mRNA. (J:53261)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nrtn Mutation: 12 strains or lines available

References

• Original: J:53261 Heuckeroth RO, et al., Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons. Neuron. 1999 Feb;22(2):253-63
• All: 19 reference(s)