Tg(tetO-cre)LC1Bjd
Transgene Detail

Summary

• Symbol: Tg(tetO-cre)LC1Bjd
• Name: transgene insertion LC1, Hermann Bujard
• MGI ID: MGI:2448952
• Synonyms: LC-1, LC1-Cre, Tg^LC1, TRE-LC1
• Transgene: Tg(tetO-cre)LC1Bjd Location: unknown Genetic Position: Chr6, Syntenic
• Alliance: Tg(tetO-cre)LC1Bjd page

Transgene origin

• Strain of Origin: (C57BL/6 x BALB/c)F2

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-cre)LC1Bjd expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  bacteria	tetO

• Mutation details: The transgenic construct contained a bidirectional tTA/rtTA responsive promoter derived from the human cytomegalovirus promoter IE and flanked by sequence encoding luciferase and cre recombinase. Efficient cre mediated recombination, unaffected by position effect variegation, was demonstrated in hepatocytes. Transcription of in both directions was shown to be activated by rtTA in the presence of doxycycline. Transgene insertion is on chromosome 6C1 flanked by genes coding for the vomeronasal receptors V1rc14 and V1rc15 (K.Schonig, pers. commun.) (J:81196)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	tetO (bacteria) Summary of all recombinase alleles driven by tetO.

Disease models

Expression

In Mice Carrying this Mutation:

27 assay results

Tumor Data

List all tumor models in MMHCdb carrying Tg(tetO-cre)LC1Bjd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.

References

• Original: J:81196 Schonig K, et al., Stringent doxycycline dependent control of CRE recombinase in vivo. Nucleic Acids Res. 2002 Dec 1;30(23):e134
• All: 137 reference(s)