Lrp5^tm1Jsak
Targeted Allele Detail

Summary

• Symbol: Lrp5^tm1Jsak
• Name: low density lipoprotein receptor-related protein 5; targeted mutation 1, Juro Sakai
• MGI ID: MGI:2448955
• Synonyms: LRP5-
• Gene: Lrp5 Location: Chr19:3634828-3736564 bp, - strand Genetic Position: Chr19, 3.33 cM, cytoband B
• Alliance: Lrp5^tm1Jsak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81174
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 18 was disrupted by a neomycin selection cassette inserted by homologous recombination. Neither normal transcript nor normal protein was detected by Northern and Western blot analyses of liver tissue obtained from homozygous mutant mice. (J:81174)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp5 Mutation: 82 strains or lines available

References

• Original: J:81174 Fujino T, et al., Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):229-34
• All: 2 reference(s)