Fgfr1^tm1Jpa
Targeted Allele Detail

Summary

• Symbol: Fgfr1^tm1Jpa
• Name: fibroblast growth factor receptor 1; targeted mutation 1, Juha Partanen
• MGI ID: MGI:2448986
• Synonyms: Fgfr1^f, Fgfr1^flox
• Gene: Fgfr1 Location: Chr8:26008808-26067819 bp, + strand Genetic Position: Chr8, 14.12 cM
• Alliance: Fgfr1^tm1Jpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81179
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Several steps of homologous and cre-mediated recombination left single loxP sites flanking exons 8 through 15. The floxed exons encode the transmembrane domain, juxtamembrane domain, and most of the tyrosine kinase domain. (J:83004)

Expression

In Mice Carrying this Mutation:	117 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr1 Mutation: 223 strains or lines available

References

• Original: J:81179 Trokovic N, et al., Fgfr1 regulates patterning of the pharyngeal region. Genes Dev. 2003 Jan 1;17(1):141-53
• All: 67 reference(s)