Rag1^tm1Bal
Targeted Allele Detail

Summary

• Symbol: Rag1^tm1Bal
• Name: recombination activating 1; targeted mutation 1, David Baltimore
• MGI ID: MGI:2448994
• Synonyms: Rag-1^-
• Gene: Rag1 Location: Chr2:101468627-101479846 bp, - strand Genetic Position: Chr2, 53.88 cM
• Alliance: Rag1^tm1Bal page

Premature death and kidney disease in C1galt1^ptl1/C1galt1^ptl1 and C1galt1^ptl1/C1galt1^ptl1 Rag1^tm1Bal/Rag1^tm1Bal mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:18049
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into the coding region at amino acid 330 resulting in a frameshift mutation. (J:18049, J:92470)

Expression

In Mice Carrying this Mutation:

2 assay results 1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Rag1^tm1Bal

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Rag1 Mutation: 123 strains or lines available

References

• Original: J:18049 Spanopoulou E, et al., Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev. 1994 May 1;8(9):1030-42
• All: 87 reference(s)