Ncoa6^tm1.1Jkr
Targeted Allele Detail

Summary

• Symbol: Ncoa6^tm1.1Jkr
• Name: nuclear receptor coactivator 6; targeted mutation 1.1, Janardan K Reddy
• MGI ID: MGI:2448999
• Synonyms: PRIP^-
• Gene: Ncoa6 Location: Chr2:155232585-155315741 bp, - strand Genetic Position: Chr2, 77.26 cM, cytoband H2
• Alliance: Ncoa6^tm1.1Jkr page

Developmental retardation and abnormalities in Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr E12.5 mutants

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81217
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Floxed exon 7 was deleted via cre-mediated homologous recombination by mating Ncoa6^tm1Jkr animals to the cre deleter strain TgN(EIIa-cre)C5379Lmgd. Homozygous mutant embryos were detected by PCR genotyping up to day E13.5 but did not survive until birth. (J:81217)

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncoa6 Mutation: 101 strains or lines available

References

• Original: J:81217 Zhu YJ, et al., Coactivator PRIP, the Peroxisome Proliferator-activated Receptor-interacting Protein, Is a Modulator of Placental, Cardiac, Hepatic, and Embryonic Development. J Biol Chem. 2003 Jan 17;278(3):1986-90
• All: 1 reference(s)