Itgb1bp2^tm1Tron
Targeted Allele Detail

Summary

• Symbol: Itgb1bp2^tm1Tron
• Name: integrin beta 1 binding protein 2; targeted mutation 1, Guido Tarone
• MGI ID: MGI:2449013
• Synonyms: melusin-null
• Gene: Itgb1bp2 Location: ChrX:100492694-100497147 bp, + strand Genetic Position: ChrX, 44.17 cM, cytoband D
• Alliance: Itgb1bp2^tm1Tron page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81163
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Disruption caused by insertion of vector
• Mutation details: The gene was disrupted by replacement of exons 1-4 with a lacZ-neo cassette via homologous recombination. Western blot analysis of skeletal and cardiac muscle proteins confirmed the absence of gene expression in homozygous mutant animals. (J:81163)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb1bp2 Mutation: 5 strains or lines available

References

• Original: J:81163 Brancaccio M, et al., Melusin, a muscle-specific integrin beta(1)-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Nat Med. 2003 Jan;9(1):68-75
• All: 1 reference(s)