Sox2^tm1Rlb
Targeted Allele Detail

Summary

• Symbol: Sox2^tm1Rlb
• Name: SRY (sex determining region Y)-box 2; targeted mutation 1, Robin Lovell-Badge
• MGI ID: MGI:2449045
• Synonyms: Sox2^betageo
• Gene: Sox2 Location: Chr3:34704554-34706610 bp, + strand Genetic Position: Chr3, 16.93 cM, cytoband A2-B
• Alliance: Sox2^tm1Rlb page

Male Sox2^tm1Rlb/Sox2⁺ mice exhibit small testes with sperm blockage in the seminiferous tubules

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81180
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of the gene was replaced with a beta-geo cassette via homologous recombination. LacZ staining in heterozygous embyros showed an expression pattern similar to that of endogenous Sox2. (J:81180)

Expression

In Mice Carrying this Mutation:	33 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox2 Mutation: 56 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Pituitary Hormone Deficiency, Combined (J:114458)

References

• Original: J:81180 Avilion AA, et al., Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev. 2003 Jan 1;17(1):126-40
• All: 12 reference(s)