Grip1^tm1Paw
Targeted Allele Detail

Summary

• Symbol: Grip1^tm1Paw
• Name: glutamate receptor interacting protein 1; targeted mutation 1, Anthony Pawson
• MGI ID: MGI:2449094
• Synonyms: GRIP1^-
• Gene: Grip1 Location: Chr10:119289810-119923172 bp, + strand Genetic Position: Chr10, 67.33 cM, cytoband D2
• Alliance: Grip1^tm1Paw page

Development of a severe bullous disorder in Grip1^tm1Paw/Grip1^tm1Paw embryos

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79476
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.6 kb fragment was replaced with a beta-galactosidase gene followed by a floxed neo gene. The deleted region included a 3' portion of the exon encoding the first PDZ domain. No full length protein was detected by Western blot analysis of protein extracts obtained from homozygous mutant embryos. Beta-galactosidase staining indicated that the reporter gene was expressed via the endogenous promoter. (J:79476)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grip1 Mutation: 93 strains or lines available

References

• Original: J:79476 Bladt F, et al., Epidermolysis bullosa and embryonic lethality in mice lacking the multi-PDZ domain protein GRIP1. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6816-21
• All: 3 reference(s)