Vamp1^lew
Spontaneous Allele Detail

Summary

• Symbol: Vamp1^lew
• Name: vesicle-associated membrane protein 1; lethal wasting
• MGI ID: MGI:2449158
• Synonyms: Syb1^lew
• Gene: Vamp1 Location: Chr6:125192544-125199269 bp, + strand Genetic Position: Chr6, 59.32 cM
• Alliance: Vamp1^lew page

Mutation origin

• Strain of Origin: C3H/HeSnJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A spontaneous mutant identified at The Jackson Laboratory. A c.190G>T transversion creates a premature stop codon at glutamic acid codon 64 (p.E64*). The predicted protein that results would lack both a transmembrane domain and a calmodulin interaction domain. mRNA levels are severely reduced and no protein can be detected by immunohistochemistry in the brain. (J:148602)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vamp1 Mutation: 7 strains or lines available

References

• Original: J:81354 Harris BS, et al., Lethal Wasting (lew), a New Prewean Lethal Mouse Mutation on Chromosome 6, 2003, Mouse Mutant Resource Web Site, The Jackson Laboratory, Bar Harbor, Maine. World Wide Web. MGI Direct Data Submission. 2003
• All: 6 reference(s)