Tg(TIE2-lacZ)182Sato
Transgene Detail

Summary

• Symbol: Tg(TIE2-lacZ)182Sato
• Name: transgene insertion 182, Thomas N Sato
• MGI ID: MGI:2449204
• Synonyms: Tg182Sato, Tg(TIE2LacZ)182Sato, Tie2-lacZ, Tie2/LacZ, TIE2p/e-LacZ
• Transgene: Tg(TIE2-lacZ)182Sato Location: unknown
• Alliance: Tg(TIE2-lacZ)182Sato page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The transgene consists of a mouse Tek promoter (2.1 kb HindIII segment including most of exon1), a lacZ reporter gene, a Tek1 enhancer element, and an SV40 polyadenylation sequence. The enhancer element is 1.7 kb genomic sequence (XhoI-KpnI restriction fragment) from inside the 5' half of intron 1. Expression was driven in endothelial cells. (J:39276)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

In embryonic and adult transgenic mice on an FVB/N background, LacZ is expressed specifically in vascular endothelial cells.

References

• Original: J:39276 Schlaeger TM, et al., Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3058-63
• All: 45 reference(s)