Myf5^{tm2(Fgf6)Thbr}
Targeted Allele Detail

Summary

• Symbol: Myf5^{tm2(Fgf6)Thbr}
• Name: myogenic factor 5; targeted mutation 2, Thomas Braun
• MGI ID: MGI:2449208
• Synonyms: Myf-5^FGF-6-ki
• Gene: Myf5 Location: Chr10:107318769-107321995 bp, - strand Genetic Position: Chr10, 55.95 cM
• Alliance: Myf5^{tm2(Fgf6)Thbr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63517
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Deletion of all Myf5 coding sequences and replacement with an IRES-Fgf6 cDNA followed by a stop codon. A lox-P flanked neomycin cassette was also inserted downstream of FGF cDNA insertion site, but was removed via Cre-mediated recombination in ES cells prior to the generation of chimeric founder mice. This allele expresses an FGF6 transcript under the control of the Myf5 promoter. (J:63517)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myf5 Mutation: 17 strains or lines available

References

• Original: J:63517 Kaul A, et al., Myf-5 revisited: loss of early myotome formation does not lead to a rib phenotype in homozygous Myf-5 mutant mice. Cell. 2000 Jul 7;102(1):17-9
• All: 1 reference(s)