Pck1^tm1.2Mgn
Targeted Allele Detail

Summary

• Symbol: Pck1^tm1.2Mgn
• Name: phosphoenolpyruvate carboxykinase 1, cytosolic; targeted mutation 1.2, Mark A Magnuson
• MGI ID: MGI:2449284
• Synonyms: pck^del
• Gene: Pck1 Location: Chr2:172994866-173001067 bp, + strand Genetic Position: Chr2, 95.79 cM, cytoband C1-qter
• Alliance: Pck1^tm1.2Mgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63929
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele is a derivative of Pck1^tm1Mgn in which the loxP-flanked neomycin cassette and sequences including exons 4 and 5 were removed in single cells embryos by transient Cre expression. Transcripts derived from this allele were reduced by 42 and 33% in liver and brown adipose tissue of heterozygous mice. (J:63929)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pck1 Mutation: 47 strains or lines available

References

• Original: J:63929 She P, et al., Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. Mol Cell Biol. 2000 Sep;20(17):6508-17
• All: 1 reference(s)