Pck1tm1.2Mgn
Targeted Allele Detail
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Symbol: |
Pck1tm1.2Mgn |
Name: |
phosphoenolpyruvate carboxykinase 1, cytosolic; targeted mutation 1.2, Mark A Magnuson |
MGI ID: |
MGI:2449284 |
Synonyms: |
pckdel |
Gene: |
Pck1 Location: Chr2:172994866-173001067 bp, + strand Genetic Position: Chr2, 95.79 cM, cytoband C1-qter
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Alliance: |
Pck1tm1.2Mgn page
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Germline Transmission: |
Earliest citation of germline transmission:
J:63929
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Parent Cell Line: |
TL1/TL-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: This allele is a derivative of Pck1tm1Mgn in which the loxP-flanked neomycin cassette and sequences including exons 4 and 5 were removed in single cells embryos by transient Cre expression. Transcripts derived from this allele were reduced by 42 and 33% in liver and brown adipose tissue of heterozygous mice.
(J:63929)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pck1 Mutation: |
46 strains or lines available
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Original: |
J:63929 She P, et al., Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. Mol Cell Biol. 2000 Sep;20(17):6508-17 |
All: |
1 reference(s) |
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