Unc13c^tm1Bros
Targeted Allele Detail

Summary

• Symbol: Unc13c^tm1Bros
• Name: unc-13 homolog C; targeted mutation 1, Nils Brose
• MGI ID: MGI:2449467
• Synonyms: Munc13-3-deficient, Unc13c^KO
• Gene: Unc13c Location: Chr9:73386704-73876248 bp, - strand Genetic Position: Chr9, 40.8 cM
• Alliance: Unc13c^tm1Bros page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66984
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by the replacement of 2 exons encoding amino acids 1014-1066 with a neomycin resistance cassette via homologous recombination. Western blot analysis of brain proteins from homozygous mutant animals confirmed the null allele. (J:66984)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Unc13c Mutation: 118 strains or lines available

References

• Original: J:66984 Augustin I, et al., The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice. J Neurosci. 2001 Jan 1;21(1):10-7
• All: 11 reference(s)