Pcyox1^tm1Sgy
Targeted Allele Detail

Summary

• Symbol: Pcyox1^tm1Sgy
• Name: prenylcysteine oxidase 1; targeted mutation 1, Stephen G Young
• MGI ID: MGI:2449567
• Synonyms: Pcly -, Pcyox1^tm1Abe
• Gene: Pcyox1 Location: Chr6:86362988-86374132 bp, - strand Genetic Position: Chr6, 37.69 cM
• Alliance: Pcyox1^tm1Sgy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79474
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neomycin selection cassette replaced exon 6, which encodes the carboxy-terminus of the protein. Northern blot analysis on RNA derived from various tissues of homozygous mice demonstrated that truncated transcripts were expressed from this allele. (J:79474)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcyox1 Mutation: 26 strains or lines available

References

• Original: J:79474 Beigneux A, et al., Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver. J Biol Chem. 2002 Oct 11;277(41):38358-63
• All: 3 reference(s)