Gdf11^tm1Clf
Targeted Allele Detail

Summary

• Symbol: Gdf11^tm1Clf
• Name: growth differentiation factor 11; targeted mutation 1, Anne L Calof
• MGI ID: MGI:2449673
• Synonyms: Gdf11^tm2
• Gene: Gdf11 Location: Chr10:128718164-128727587 bp, - strand Genetic Position: Chr10, 77.18 cM, cytoband D3
• Alliance: Gdf11^tm1Clf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81451
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 3 was disrupted by the insertion of a PGK-neo cassette. The targeted allele putatively encodes a transcript lacking four of seven essential cysteine codons. RT-PCR analysis of total RNA obtained from olfactory turbinates indicated an absence of normal transcript in homozygous mutant embryos. (J:81451)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdf11 Mutation: 13 strains or lines available

References

• Original: J:81451 Wu HH, et al., Autoregulation of Neurogenesis by GDF11. Neuron. 2003 Jan 23;37(2):197-207
• All: 5 reference(s)